The Interplay of Cholesterol and Ligand Binding in hTSPO from Classical Molecular Dynamics Simulations

The translocator protein (TSPO) is a 18kDa transmembrane protein, ubiquitously present in human mitochondria. It is overexpressed in tumor cells and at the sites of neuroinflammation, thus representing an important biomarker, as well as a promising drug target. In mammalian TSPO, there are cholester...

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Detalles Bibliográficos
Autores principales: Lai, Hien T. T., Giorgetti, Alejandro, Rossetti, Giulia, Nguyen, Toan T., Carloni, Paolo, Kranjc, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956637/
https://www.ncbi.nlm.nih.gov/pubmed/33652554
http://dx.doi.org/10.3390/molecules26051250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956637/
https://www.ncbi.nlm.nih.gov/pubmed/33652554
http://dx.doi.org/10.3390/molecules26051250

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