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The Interplay of Cholesterol and Ligand Binding in hTSPO from Classical Molecular Dynamics Simulations
The translocator protein (TSPO) is a 18kDa transmembrane protein, ubiquitously present in human mitochondria. It is overexpressed in tumor cells and at the sites of neuroinflammation, thus representing an important biomarker, as well as a promising drug target. In mammalian TSPO, there are cholester...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956637/ https://www.ncbi.nlm.nih.gov/pubmed/33652554 http://dx.doi.org/10.3390/molecules26051250 |