Transcriptomic Changes Associated with Loss of Cell Viability Induced by Oxysterol Treatment of a Retinal Photoreceptor-Derived Cell Line: An In Vitro Model of Smith–Lemli–Opitz Syndrome

Smith–Lemli–Opitz Syndrome (SLOS) results from mutations in the gene encoding the enzyme DHCR7, which catalyzes conversion of 7-dehydrocholesterol (7DHC) to cholesterol (CHOL). Rats treated with a DHCR7 inhibitor serve as a SLOS animal model, and exhibit progressive photoreceptor-specific cell death...

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Detalles Bibliográficos
Autores principales: Pfeffer, Bruce A., Xu, Libin, Fliesler, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956713/
https://www.ncbi.nlm.nih.gov/pubmed/33652836
http://dx.doi.org/10.3390/ijms22052339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956713/
https://www.ncbi.nlm.nih.gov/pubmed/33652836
http://dx.doi.org/10.3390/ijms22052339

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