Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein

Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del, causes misfolding and premature degradation of CFTR protein. This defect can be overcome with pharmacological agents named “correctors”. So far, a...

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Detalles Bibliográficos
Autores principales: Spanò, Virginia, Barreca, Marilia, Cilibrasi, Vincenzo, Genovese, Michele, Renda, Mario, Montalbano, Alessandra, Galietta, Luis Juan Vicente, Barraja, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956813/
https://www.ncbi.nlm.nih.gov/pubmed/33652850
http://dx.doi.org/10.3390/molecules26051275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956813/
https://www.ncbi.nlm.nih.gov/pubmed/33652850
http://dx.doi.org/10.3390/molecules26051275

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