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Repurposing Melt Degradation for the Evaluation of Mixed Amorphous-Crystalline Blends

Medicine regulators require the melting points for crystalline drugs, as they are a test for chemical and physical quality. Many drugs, especially salt-forms, suffer concomitant degradation during melting; thus, it would be useful to know if the endotherm associated with melt degradation may be used...

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Detalles Bibliográficos
Autores principales: Abdul-jabbar, Sumayah, Wong, Daniel W., Martin, Gary P., Woodhead, Brendon, Royall, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956934/
https://www.ncbi.nlm.nih.gov/pubmed/33718988
http://dx.doi.org/10.1208/s12249-021-01971-6