Cargando…

Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs)

Anthracyclines are a class of chemotherapy drugs that are highly effective for the treatment of human cancers, but their clinical use is limited by associated dose-dependent cardiotoxicity. The precise mechanisms by which individual anthracycline induces cardiotoxicity are not fully understood. Huma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bozza, William P., Takeda, Kazuyo, Alterovitz, Wei-Lun, Chou, Chao-Kai, Shen, Rong-Fong, Zhang, Baolin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956936/ https://www.ncbi.nlm.nih.gov/pubmed/33719006 http://dx.doi.org/10.1208/s12248-021-00576-y

Ejemplares similares

Chronic Cardiotoxicity Assays Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs)
por: Narkar, Akshay, et al.
Publicado: (2022)

Comparison of Zebrafish Larvae and hiPSC Cardiomyocytes for Predicting Drug-Induced Cardiotoxicity in Humans
por: Dyballa, Sylvia, et al.
Publicado: (2019)

Does Enhanced Structural Maturity of hiPSC-Cardiomyocytes Better for the Detection of Drug-Induced Cardiotoxicity?
por: Van de Sande, Dieter, et al.
Publicado: (2023)

A mathematical model of hiPSC cardiomyocytes electromechanics
por: Forouzandehmehr, Mohamadamin, et al.
Publicado: (2021)

Reprogramming of HUVECs into Induced Pluripotent Stem Cells (HiPSCs), Generation and Characterization of HiPSC-Derived Neurons and Astrocytes
por: Haile, Yohannes, et al.
Publicado: (2015)

Protein-encapsulated doxorubicin reduces cardiotoxicity in hiPSC-cardiomyocytes and cardiac spheroids while maintaining anticancer efficacy
por: Arzt, Madelyn, et al.
Publicado: (2023)

An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes
por: McKeithan, Wesley L., et al.
Publicado: (2017)

Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays
por: Maria Cherian, Reeja, et al.
Publicado: (2022)

Practical adoption of state-of-the-art hiPSC-cardiomyocyte differentiation techniques
por: Rupert, Cassady E., et al.
Publicado: (2020)

An in silico hiPSC-Derived Cardiomyocyte Model Built With Genetic Algorithm
por: Akwaboah, Akwasi D., et al.
Publicado: (2021)

The Emergence of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform to Model Arrhythmogenic Diseases
por: Pourrier, Marc, et al.
Publicado: (2020)

Evaluation of chronic drug-induced electrophysiological and cytotoxic effects using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
por: Altrocchi, C., et al.
Publicado: (2023)

Lower cardiotoxicity of CPX-351 relative to daunorubicin plus cytarabine free-drug combination in hiPSC-derived cardiomyocytes in vitro
por: Fortin, Marie C., et al.
Publicado: (2023)

Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes
por: Ulmer, Bärbel M., et al.
Publicado: (2018)

Microscopy-based cellular contractility assay for adult, neonatal, and hiPSC cardiomyocytes
por: Scalzo, Sérgio, et al.
Publicado: (2022)

Generation of self-assembling cardiac organoids using hiPSC-derived cardiomyocytes
por: Künzel, Karolina, et al.
Publicado: (2022)

Merits of hiPSC-Derived Cardiomyocytes for In Vitro Research and Testing Drug Toxicity
por: Wang, Ping-Hsien, et al.
Publicado: (2022)

Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application
por: Ito, Emiko, et al.
Publicado: (2019)

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Do not Improve with Carnitine Supplementation
por: Verkerk, Arie O., et al.
Publicado: (2021)

Sarc-Graph: Automated segmentation, tracking, and analysis of sarcomeres in hiPSC-derived cardiomyocytes
por: Zhao, Bill, et al.
Publicado: (2021)

Expression of Extracellular Vesicle PIWI-Interacting RNAs Throughout hiPSC-Cardiomyocyte Differentiation
por: Louro, Ana F., et al.
Publicado: (2022)

Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch
por: Khan, Mahmood, et al.
Publicado: (2015)

Comparative characterization of human induced pluripotent stem cells (hiPSC) derived from patients with schizophrenia and autism
por: Grunwald, Lena-Marie, et al.
Publicado: (2019)

Differentiation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons in Mouse Hippocampal Slice Cultures
por: Hiragi, Toshimitsu, et al.
Publicado: (2017)

Efficient Differentiation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Mesenchymal Progenitors Into Adipocytes and Osteoblasts
por: Diaz-Hernandez, Martha Elena, et al.
Publicado: (2023)

Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates
por: Pioner, Josè Manuel, et al.
Publicado: (2019)

Modeling Cardiovascular Diseases with hiPSC-Derived Cardiomyocytes in 2D and 3D Cultures
por: Sacchetto, Claudia, et al.
Publicado: (2020)

Electrophysiology of hiPSC-Cardiomyocytes Co-Cultured with HEK Cells Expressing the Inward Rectifier Channel
por: Costa, Ana Da Silva, et al.
Publicado: (2021)

Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery
por: Huang, Guanyi, et al.
Publicado: (2022)

Correction: Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch
por: Khan, Mahmood, et al.
Publicado: (2015)

Empagliflozin and Dapagliflozin Increase Na(+) and Inward Rectifier K(+) Current Densities in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells (hiPSC-CMs)
por: Dago, María, et al.
Publicado: (2022)

hiPSC-Derived Cells as Models for Drug Discovery
por: Ofir, Rivka
Publicado: (2021)

Characterizing the secretome of licensed hiPSC-derived MSCs
por: Ramos, Yolande F. M., et al.
Publicado: (2022)

Transcriptomic profiling reveals p53 as a key regulator of doxorubicin-induced cardiotoxicity
por: McSweeney, K. Melodi, et al.
Publicado: (2019)

Generation of hiPSC-Derived Skeletal Muscle Cells: Exploiting the Potential of Skeletal Muscle-Derived hiPSCs
por: Metzler, Eric, et al.
Publicado: (2022)

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes
por: Josowitz, Rebecca, et al.
Publicado: (2016)

Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation
por: Lodola, Francesco, et al.
Publicado: (2021)

Thyroid hormones regulate cardiac repolarization and QT-interval related gene expression in hiPSC cardiomyocytes
por: Ulivieri, Alessandra, et al.
Publicado: (2022)

An allied reprogramming, selection, expansion and differentiation platform for creating hiPSC on microcarriers
por: Lam, Alan Tin Lun, et al.
Publicado: (2022)

In-Depth Characterisation of Retinal Pigment Epithelium (RPE) Cells Derived from Human Induced Pluripotent Stem Cells (hiPSC)
por: Brandl, Caroline, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_2fe5ajet95or27bdhjuao98uaf