Bortezomib suppresses self‐renewal and leukemogenesis of leukemia stem cell by NF‐ĸB‐dependent inhibition of CDK6 in MLL‐rearranged myeloid leukemia

Acute myeloid leukaemia (AML) with chromosomal rearrangements involving the H3K4 methyltransferase mixed‐lineage leukaemia (MLL) is an aggressive subtype with low overall survival. Bortezomib (Bort) is first applied in multiple myeloma. However, whether bort possesses anti‐self‐renewal and leukemoge...

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Detalles Bibliográficos
Autores principales: Zhou, Bin, Qin, Yaqian, Zhou, Jingying, Ruan, Jichen, Xiong, Fang, Dong, Jinglai, Huang, Xingzhou, Yu, Zhijie, Gao, Shenmeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957264/
https://www.ncbi.nlm.nih.gov/pubmed/33599085
http://dx.doi.org/10.1111/jcmm.16377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957264/
https://www.ncbi.nlm.nih.gov/pubmed/33599085
http://dx.doi.org/10.1111/jcmm.16377

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