Claulansine F–Donepezil Hybrids as Anti-Alzheimer’s Disease Agents with Cholinergic, Free-Radical Scavenging, and Neuroprotective Activities

The multifactorial nature of Alzheimer’s disease (AD) calls for the development of multitarget agents addressing key pathogenic processes. A total of 26 Claulansine F–donepezil hybrids were designed and synthesized as multitarget drugs. Among these compounds, six compounds exhibited excellent acetyl...

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Detalles Bibliográficos
Autores principales: Zang, Yingda, Liu, Ke, Wang, Weiping, Li, Chuangjun, Ma, Jie, Yang, Jingzhi, Chen, Xinyi, Wang, Xiaoliang, Zhang, Dongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957565/
https://www.ncbi.nlm.nih.gov/pubmed/33671020
http://dx.doi.org/10.3390/molecules26051303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957565/
https://www.ncbi.nlm.nih.gov/pubmed/33671020
http://dx.doi.org/10.3390/molecules26051303

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