Structure of the Signal Transduction Domain in Second-Generation CAR Regulates the Input Efficiency of CAR Signals

T cells that are genetically engineered to express chimeric antigen receptor (CAR) have a strong potential to eliminate tumor cells, yet the CAR-T cells may also induce severe side effects due to an excessive immune response. Although optimization of the CAR structure is expected to improve the effi...

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Detalles Bibliográficos
Autores principales: Fujiwara, Kento, Kitaura, Masaki, Tsunei, Ayaka, Kusabuka, Hotaka, Ogaki, Erika, Okada, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957710/
https://www.ncbi.nlm.nih.gov/pubmed/33804441
http://dx.doi.org/10.3390/ijms22052476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957710/
https://www.ncbi.nlm.nih.gov/pubmed/33804441
http://dx.doi.org/10.3390/ijms22052476

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