The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin

[Image: see text] Furin activates numerous viral glycoproteins, and its inhibition prevents virus replication and spread. Through the replacement of arginine by the less basic canavanine, new inhibitors targeting furin in the trans-Golgi network were developed. These inhibitors exert potent antivira...

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Detalles Bibliográficos
Autores principales: Lam van, Thuy Van, Heindl, Miriam Ruth, Schlutt, Christine, Böttcher-Friebertshäuser, Eva, Bartenschlager, Ralf, Klebe, Gerhard, Brandstetter, Hans, Dahms, Sven O., Steinmetzer, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957917/
https://www.ncbi.nlm.nih.gov/pubmed/33732412
http://dx.doi.org/10.1021/acsmedchemlett.0c00651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957917/
https://www.ncbi.nlm.nih.gov/pubmed/33732412
http://dx.doi.org/10.1021/acsmedchemlett.0c00651

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