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Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis

Blood pH is tightly maintained between 7.35 and 7.45, and acidosis (pH <7.3) indicates poor prognosis in sepsis, wherein lactic acid from anoxic tissues overwhelms the buffering capacity of blood. Poor sepsis prognosis is also associated with low zinc levels and the release of High mobility group...

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Detalles Bibliográficos
Autores principales: Siddiqui, Shoib S., Dhar, Chirag, Sundaramurthy, Venkatasubramaniam, Sasmal, Aniruddha, Yu, Hai, Bandala-Sanchez, Esther, Li, Miaomiao, Zhang, Xiaoxiao, Chen, Xi, Harrison, Leonard C., Xu, Ding, Varki, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958265/
https://www.ncbi.nlm.nih.gov/pubmed/33658363
http://dx.doi.org/10.1073/pnas.2018090118