Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis

SIMPLE SUMMARY: Chromosome instability (CIN) promotes cancer initiation and progression, but its genetic origins remain largely unknown. As aberrant mitotic processes such as chromatin compaction defects can induce CIN, characterizing the molecular determinants of mitotic fidelity may reveal novel C...

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Detalles Bibliográficos
Autores principales: Jeusset, Lucile M., Guppy, Brent J., Lichtensztejn, Zelda, McDonald, Darin, McManus, Kirk J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958346/
https://www.ncbi.nlm.nih.gov/pubmed/33801331
http://dx.doi.org/10.3390/cancers13051043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958346/
https://www.ncbi.nlm.nih.gov/pubmed/33801331
http://dx.doi.org/10.3390/cancers13051043

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