Cargando…

Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis

SIMPLE SUMMARY: Chromosome instability (CIN) promotes cancer initiation and progression, but its genetic origins remain largely unknown. As aberrant mitotic processes such as chromatin compaction defects can induce CIN, characterizing the molecular determinants of mitotic fidelity may reveal novel C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeusset, Lucile M., Guppy, Brent J., Lichtensztejn, Zelda, McDonald, Darin, McManus, Kirk J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958346/ https://www.ncbi.nlm.nih.gov/pubmed/33801331 http://dx.doi.org/10.3390/cancers13051043

Ejemplares similares

Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis
por: Baergen, Allison K., et al.
Publicado: (2019)

Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes
por: Leylek, Tarik R., et al.
Publicado: (2020)

Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells
por: Sajesh, Babu V, et al.
Publicado: (2013)

Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover
por: Thompson, Laura L., et al.
Publicado: (2020)

Mitotic Accumulation of Dimethylated Lysine 79 of Histone H3 Is Important for Maintaining Genome Integrity During Mitosis in Human Cells
por: Guppy, Brent J., et al.
Publicado: (2015)

Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer
por: Thompson, Laura L., et al.
Publicado: (2017)

Synthetic Genetic Targeting of Genome Instability in Cancer
por: Sajesh, Babu V., et al.
Publicado: (2013)

Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer
por: Jeusset, Lucile M-P., et al.
Publicado: (2017)

Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer
por: Jeusset, Lucile M-P, et al.
Publicado: (2019)

The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples
por: Penner-Goeke, Signe, et al.
Publicado: (2017)

Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills RAD54B-Deficient Colorectal Cancer Cells
por: Sajesh, Babu V., et al.
Publicado: (2013)

Reduced SKP2 Expression Adversely Impacts Genome Stability and Promotes Cellular Transformation in Colonic Epithelial Cells
por: Neudorf, Nicole M., et al.
Publicado: (2022)

Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer
por: Lepage, Chloe Camille, et al.
Publicado: (2021)

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
por: Arkinson, Connor, et al.
Publicado: (2018)

The F-box protein, FBXO7, is required to maintain chromosome stability in humans
por: Palmer, Michaela C L, et al.
Publicado: (2021)

Characterizing the Prevalence of Chromosome Instability in Interval Colorectal Cancer()()
por: Cisyk, A.L., et al.
Publicado: (2015)

Chromatin structure related to oncogenesis
por: Matsumoto, Syota, et al.
Publicado: (2023)

USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability
por: Qian, Jiang, et al.
Publicado: (2014)

The Adenomatous Polyposis Coli Protein Contributes to Normal Compaction of Mitotic Chromatin
por: Dikovskaya, Dina, et al.
Publicado: (2012)

Mitotic post-translational modifications of histones promote chromatin compaction in vitro
por: Zhiteneva, Alisa, et al.
Publicado: (2017)

Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes
por: Vishwakarma, Raghvendra, et al.
Publicado: (2020)

Cold‐induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm
por: Fischl, Harry, et al.
Publicado: (2020)

Axial contraction and short-range compaction of chromatin synergistically promote mitotic chromosome condensation
por: Kruitwagen, Tom, et al.
Publicado: (2015)

Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers
por: Cisyk, Amy L., et al.
Publicado: (2018)

Monoubiquitination in Homeostasis and Cancer
por: Chen, Yujie, et al.
Publicado: (2022)

Histone Monoubiquitination in Chromatin Remodelling: Focus on the Histone H2B Interactome and Cancer
por: Marsh, Deborah J., et al.
Publicado: (2020)

USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination
por: Zhang, Yana, et al.
Publicado: (2020)

A Novel Multiplexed, Image-Based Approach to Detect Phenotypes That Underlie Chromosome Instability in Human Cells
por: Thompson, Laura L., et al.
Publicado: (2015)

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction
por: Djeghloul, Dounia, et al.
Publicado: (2020)

Human papillomavirus integration transforms chromatin to drive oncogenesis
por: Karimzadeh, Mehran, et al.
Publicado: (2023)

Aberrant HMGA2 Expression Sustains Genome Instability That Promotes Metastasis and Therapeutic Resistance in Colorectal Cancer
por: Campos Gudiño, Rubi, et al.
Publicado: (2023)

USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability
por: Skowyra, Agnieszka, et al.
Publicado: (2018)

Cracking the Monoubiquitin Code of Genetic Diseases
por: Sewduth, Raj Nayan, et al.
Publicado: (2020)

Multi-monoubiquitination controls VASP-mediated actin dynamics
por: McCormick, Laura E., et al.
Publicado: (2023)

An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability
por: Lepage, Chloe C., et al.
Publicado: (2020)

Bridging condensins mediate compaction of mitotic chromosomes
por: Forte, Giada, et al.
Publicado: (2023)

Methylation of DNA and chromatin as a mechanism of oncogenesis and therapeutic target in neuroblastoma
por: Ram Kumar, Ram Mohan, et al.
Publicado: (2018)

Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis
por: Nakayama, Yuji, et al.
Publicado: (2017)

Dynamic regulation and function of histone monoubiquitination in plants
por: Feng, Jing, et al.
Publicado: (2014)

The Genetic and Biochemical Basis of FANCD2 Monoubiquitination
por: Rajendra, Eeson, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_mgi61p44q8qt2naui8m29dkubr