Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation

Kinases play important roles in diverse cellular processes, including signaling, differentiation, proliferation, and metabolism. They are frequently mutated in cancer and are the targets of a large number of specific inhibitors. Surveys of cancer genome atlases reveal that kinase domains, which cons...

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Detalles Bibliográficos
Autores principales: Patil, Keshav, Jordan, Earl Joseph, Park, Jin H., Suresh, Krishna, Smith, Courtney M., Lemmon, Abigail A., Mossé, Yaël P., Lemmon, Mark A., Radhakrishnan, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958353/
https://www.ncbi.nlm.nih.gov/pubmed/33674381
http://dx.doi.org/10.1073/pnas.2019132118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958353/
https://www.ncbi.nlm.nih.gov/pubmed/33674381
http://dx.doi.org/10.1073/pnas.2019132118

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