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HIV-1 cores retain their integrity until minutes before uncoating in the nucleus

We recently reported that HIV-1 cores that retained >94% of their capsid (CA) protein entered the nucleus and disassembled (uncoated) near their integration site <1.5 h before integration. However, whether the nuclear capsids lost their integrity by rupturing or a small loss of CA before capsi...

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Detalles Bibliográficos
Autores principales: Li, Chenglei, Burdick, Ryan C., Nagashima, Kunio, Hu, Wei-Shau, Pathak, Vinay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958386/
https://www.ncbi.nlm.nih.gov/pubmed/33649225
http://dx.doi.org/10.1073/pnas.2019467118