Cargando…

Ligand effects on phase separation of multivalent macromolecules

Biomolecular condensates enable spatial and temporal control over cellular processes by concentrating biomolecules into nonstoichiometric assemblies. Many condensates form via reversible phase transitions of condensate-specific multivalent macromolecules known as scaffolds. Phase transitions of scaf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruff, Kiersten M., Dar, Furqan, Pappu, Rohit V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958451/ https://www.ncbi.nlm.nih.gov/pubmed/33653957 http://dx.doi.org/10.1073/pnas.2017184118

Ejemplares similares

Polyphasic linkage and the impact of ligand binding on the regulation of biomolecular condensates
por: Ruff, Kiersten M., et al.
Publicado: (2021)

LASSI: A lattice model for simulating phase transitions of multivalent proteins
por: Choi, Jeong-Mo, et al.
Publicado: (2019)

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins
por: Harmon, Tyler S, et al.
Publicado: (2017)

Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins
por: Zeng, Xiangze, et al.
Publicado: (2022)

Connecting sequence features within the disordered C-terminal linker of Bacillus subtilis FtsZ to functions and bacterial cell division
por: Shinn, Min Kyung, et al.
Publicado: (2022)

Dilute phase oligomerization can oppose phase separation and modulate material properties of a ribonucleoprotein condensate
por: Seim, Ian, et al.
Publicado: (2022)

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions
por: Kar, Mrityunjoy, et al.
Publicado: (2022)

Information theoretic measures for quantifying sequence–ensemble relationships of intrinsically disordered proteins
por: Cohan, Megan C, et al.
Publicado: (2019)

Restricting the sizes of condensates
por: Dar, Furqan, et al.
Publicado: (2020)

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity
por: Duff,, Michael R., et al.
Publicado: (2011)

Mesoscale structure–function relationships in mitochondrial transcriptional condensates
por: Feric, Marina, et al.
Publicado: (2022)

Dynamical control enables the formation of demixed biomolecular condensates
por: Lin, Andrew Z., et al.
Publicado: (2023)

Mechanistic Inferences From Analysis of Measurements of Protein Phase Transitions in Live Cells
por: Posey, Ammon E., et al.
Publicado: (2021)

Permeation of macromolecules into the renal glomerular basement membrane and capture by the tubules
por: Lawrence, Marlon G., et al.
Publicado: (2017)

Role of non-specific interactions in the phase-separation and maturation of macromolecules
por: Krishnan, Rakesh, et al.
Publicado: (2022)

Dynamical control enables the formation of demixed biomolecular condensates
por: Lin, Andrew Z., et al.
Publicado: (2023)

Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins
por: Berlow, Rebecca B., et al.
Publicado: (2022)

Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions
por: Crick, Scott L., et al.
Publicado: (2006)

Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions
por: Farag, Mina, et al.
Publicado: (2023)

Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3
por: Chiu, Yi-Ping, et al.
Publicado: (2020)

Functional lipid pairs as building blocks of phase-separated membranes
por: Soloviov, Dmytro, et al.
Publicado: (2020)

Multivalent polymers can control phase boundary, dynamics, and organization of liquid-liquid phase separation
por: Zumbro, Emiko, et al.
Publicado: (2021)

Multivalency of nucleosome recognition by LEDGF
por: Koutná, Eliška, et al.
Publicado: (2023)

Inert and seed-competent tau monomers suggest structural origins of aggregation
por: Mirbaha, Hilda, et al.
Publicado: (2018)

Phase transitions of multivalent proteins can promote clustering of membrane receptors
por: Banjade, Sudeep, et al.
Publicado: (2014)

3D visualization of macromolecule synthesis
por: Duerr, Timothy J, et al.
Publicado: (2020)

Phase-separation physics underlies new theory for the resilience of patchy ecosystems
por: Siteur, Koen, et al.
Publicado: (2023)

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
por: Warner, John B., et al.
Publicado: (2017)

TDP-43 α-helical structure tunes liquid–liquid phase separation and function
por: Conicella, Alexander E., et al.
Publicado: (2020)

Generation of dynamic three-dimensional genome structure through phase separation of chromatin
por: Fujishiro, Shin, et al.
Publicado: (2022)

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau
por: Ash, Peter E. A., et al.
Publicado: (2021)

Photoswitching Affinity and Mechanism of Multivalent Lectin Ligands
por: Osswald, Uwe, et al.
Publicado: (2022)

Yeast cells actively tune their membranes to phase separate at temperatures that scale with growth temperatures
por: Leveille, Chantelle L., et al.
Publicado: (2022)

Global profiling of arginine dimethylation in regulating protein phase separation by a steric effect–based chemical-enrichment method
por: Wang, Qi, et al.
Publicado: (2022)

Phase Separation in Mixtures of Prion-Like Low Complexity Domains is Driven by the Interplay of Homotypic and Heterotypic Interactions
por: Pappu, Rohit, et al.
Publicado: (2023)

Phase separation by ssDNA binding protein controlled via protein−protein and protein−DNA interactions
por: Harami, Gábor M., et al.
Publicado: (2020)

Liquid–liquid phase separation of type II diabetes-associated IAPP initiates hydrogelation and aggregation
por: Pytowski, Lior, et al.
Publicado: (2020)

Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid–liquid phase separation
por: Ladouceur, Anne-Marie, et al.
Publicado: (2020)

Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation
por: Jin, Chen, et al.
Publicado: (2022)

Self-construction of actin networks through phase separation–induced abLIM1 condensates
por: Yang, Sen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_830sr2avk32490dsm6jp065vuv