A versatile platform for locus-scale genome rewriting and verification

Routine rewriting of loci associated with human traits and diseases would facilitate their functional analysis. However, existing DNA integration approaches are limited in terms of scalability and portability across genomic loci and cellular contexts. We describe Big-IN, a versatile platform for tar...

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Detalles Bibliográficos
Autores principales: Brosh, Ran, Laurent, Jon M., Ordoñez, Raquel, Huang, Emily, Hogan, Megan S., Hitchcock, Angela M., Mitchell, Leslie A., Pinglay, Sudarshan, Cadley, John A., Luther, Raven D., Truong, David M., Boeke, Jef D., Maurano, Matthew T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958457/
https://www.ncbi.nlm.nih.gov/pubmed/33649239
http://dx.doi.org/10.1073/pnas.2023952118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958457/
https://www.ncbi.nlm.nih.gov/pubmed/33649239
http://dx.doi.org/10.1073/pnas.2023952118

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