Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2

[Image: see text] Covalently acting inhibitors constitute a large and growing fraction of approved small-molecule therapeutics as well as useful tools for a variety of in vitro and in vivo applications. Here, we aimed to develop a covalent antagonist of CC chemokine receptor 2 (CCR2), a class A GPCR...

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Detalles Bibliográficos
Autores principales: Ortiz Zacarías, Natalia V., Chahal, Kirti K., Šimková, Tereza, van der Horst, Cas, Zheng, Yi, Inoue, Asuka, Theunissen, Emy, Mallee, Lloyd, van der Es, Daan, Louvel, Julien, IJzerman, Adriaan P., Handel, Tracy M., Kufareva, Irina, Heitman, Laura H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958898/
https://www.ncbi.nlm.nih.gov/pubmed/33600174
http://dx.doi.org/10.1021/acs.jmedchem.0c01137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958898/
https://www.ncbi.nlm.nih.gov/pubmed/33600174
http://dx.doi.org/10.1021/acs.jmedchem.0c01137

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