MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria

Mutations in mitochondrial replicative polymerase PolγA lead to progressive external ophthalmoplegia (PEO). While PolγA is the known central player in mitochondrial DNA (mtDNA) replication, it is unknown whether a regulatory process exists on the mitochondrial outer membrane which controlled its ent...

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Detalles Bibliográficos
Autores principales: Hussain, Mansoor, Mohammed, Aftab, Saifi, Shabnam, Khan, Aamir, Kaur, Ekjot, Priya, Swati, Agarwal, Himanshi, Sengupta, Sagar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959396/
https://www.ncbi.nlm.nih.gov/pubmed/33657094
http://dx.doi.org/10.1371/journal.pbio.3001139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959396/
https://www.ncbi.nlm.nih.gov/pubmed/33657094
http://dx.doi.org/10.1371/journal.pbio.3001139

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