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MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria
Mutations in mitochondrial replicative polymerase PolγA lead to progressive external ophthalmoplegia (PEO). While PolγA is the known central player in mitochondrial DNA (mtDNA) replication, it is unknown whether a regulatory process exists on the mitochondrial outer membrane which controlled its ent...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959396/ https://www.ncbi.nlm.nih.gov/pubmed/33657094 http://dx.doi.org/10.1371/journal.pbio.3001139 |