P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition

Chronic neurodegeneration in survivors of traumatic brain injury (TBI) is a major cause of morbidity, with no effective therapies to mitigate this progressive and debilitating form of nerve cell death. Here, we report that pharmacologic restoration of the blood–brain barrier (BBB), 12 mo after murin...

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Detalles Bibliográficos
Autores principales: Vázquez-Rosa, Edwin, Shin, Min-Kyoo, Dhar, Matasha, Chaubey, Kalyani, Cintrón-Pérez, Coral J., Tang, Xinmiao, Liao, Xudong, Miller, Emiko, Koh, Yeojung, Barker, Sarah, Franke, Kathryn, Crosby, Danyel R., Schroeder, Rachel, Emery, Josie, Yin, Terry C., Fujioka, Hisashi, Reynolds, James D., Harper, Matthew M., Jain, Mukesh K., Pieper, Andrew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959512/
https://www.ncbi.nlm.nih.gov/pubmed/33087571
http://dx.doi.org/10.1073/pnas.2010430117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959512/
https://www.ncbi.nlm.nih.gov/pubmed/33087571
http://dx.doi.org/10.1073/pnas.2010430117

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