Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling

Cyclic dinucleotides (CDNs) are secondary messengers used by prokaryotic and eukaryotic cells. In mammalian cells, cytosolic CDNs bind STING (stimulator of IFN gene), resulting in the production of type I IFN. Extracellular CDNs can enter the cytosol through several pathways but how CDNs work from o...

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Detalles Bibliográficos
Autores principales: Chang, Denis, Whiteley, Aaron T., Bugda Gwilt, Katlynn, Lencer, Wayne I., Mekalanos, John J., Thiagarajah, Jay R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959571/
https://www.ncbi.nlm.nih.gov/pubmed/33087577
http://dx.doi.org/10.1073/pnas.2015919117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959571/
https://www.ncbi.nlm.nih.gov/pubmed/33087577
http://dx.doi.org/10.1073/pnas.2015919117

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