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USP11 mediates repair of DNA–protein cross-links by deubiquitinating SPRTN metalloprotease
DNA–protein cross-links (DPCs) are toxic DNA lesions that interfere with DNA metabolic processes such as replication, transcription, and recombination. USP11 deubiquitinase participates in DNA repair, but the role of USP11 in DPC repair is not known. SPRTN is a replication-coupled DNA-dependent meta...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960550/ https://www.ncbi.nlm.nih.gov/pubmed/33567341 http://dx.doi.org/10.1016/j.jbc.2021.100396 |