Inhibition of mTOR signaling by genetic removal of p70 S6 kinase 1 increases anxiety-like behavior in mice

The mechanistic target of rapamycin (mTOR) is a ubiquitously expressed kinase that acts through two complexes, mTORC1 and mTORC2, to regulate protein homeostasis, as well as long lasting forms of synaptic and behavioral plasticity. Alteration of the mTOR pathway is classically involved in neurodegen...

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Detalles Bibliográficos
Autores principales: Koehl, Muriel, Ladevèze, Elodie, Catania, Caterina, Cota, Daniela, Abrous, Djoher Nora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960700/
https://www.ncbi.nlm.nih.gov/pubmed/33723223
http://dx.doi.org/10.1038/s41398-020-01187-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960700/
https://www.ncbi.nlm.nih.gov/pubmed/33723223
http://dx.doi.org/10.1038/s41398-020-01187-5

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