Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation

Protein homeostasis is modulated by stress response pathways and its deficiency is a hallmark of aging. The integrated stress response (ISR) is a conserved stress-signaling pathway that tunes mRNA translation via phosphorylation of the translation initiation factor eIF2. ISR activation and translati...

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Detalles Bibliográficos
Autores principales: Derisbourg, Maxime J., Wester, Laura E., Baddi, Ruth, Denzel, Martin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960713/
https://www.ncbi.nlm.nih.gov/pubmed/33723245
http://dx.doi.org/10.1038/s41467-021-21743-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960713/
https://www.ncbi.nlm.nih.gov/pubmed/33723245
http://dx.doi.org/10.1038/s41467-021-21743-x

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