Ligand modulation of the conformational dynamics of the A(2A) adenosine receptor revealed by single-molecule fluorescence

G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, making them an important target for therapeutics. Activation of these receptors is modulated by orthosteric ligands, which stabilize one or several states within a complex conformational ensemble. The intra- and int...

Descripción completa

Detalles Bibliográficos
Autores principales: Fernandes, Dennis D., Neale, Chris, Gomes, Gregory-Neal W., Li, Yuchong, Malik, Aimen, Pandey, Aditya, Orazietti, Alexander P., Wang, Xudong, Ye, Libin, Scott Prosser, R., Gradinaru, Claudiu C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960716/
https://www.ncbi.nlm.nih.gov/pubmed/33723285
http://dx.doi.org/10.1038/s41598-021-84069-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960716/
https://www.ncbi.nlm.nih.gov/pubmed/33723285
http://dx.doi.org/10.1038/s41598-021-84069-0

Ejemplares similares