Mutation of Framework Residue H71 Results in Different Antibody Paratope States in Solution

Characterizing and understanding the antibody binding interface have become a pre-requisite for rational antibody design and engineering. The antigen-binding site is formed by six hypervariable loops, known as the complementarity determining regions (CDRs) and by the relative interdomain orientation...

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Detalles Bibliográficos
Autores principales: Fernández-Quintero, Monica L., Kroell, Katharina B., Hofer, Florian, Riccabona, Jakob R., Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960778/
https://www.ncbi.nlm.nih.gov/pubmed/33737932
http://dx.doi.org/10.3389/fimmu.2021.630034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960778/
https://www.ncbi.nlm.nih.gov/pubmed/33737932
http://dx.doi.org/10.3389/fimmu.2021.630034

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