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Mutation of Framework Residue H71 Results in Different Antibody Paratope States in Solution
Characterizing and understanding the antibody binding interface have become a pre-requisite for rational antibody design and engineering. The antigen-binding site is formed by six hypervariable loops, known as the complementarity determining regions (CDRs) and by the relative interdomain orientation...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960778/ https://www.ncbi.nlm.nih.gov/pubmed/33737932 http://dx.doi.org/10.3389/fimmu.2021.630034 |