NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow in HTM/HSC Constructs

PURPOSE: NCX 667, a novel nitric oxide (NO) donor with an isomannide core, was characterized for its IOP-lowering ability in animal models of ocular hypertension and glaucoma. Bioengineered human trabecular meshwork/Schlemm's canal (HTM/HSC) constructs were used to explore the mode of action. M...

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Detalles Bibliográficos
Autores principales: Bastia, Elena, Toris, Carol B., Brambilla, Stefania, Galli, Corinna, Almirante, Nicoletta, Bergamini, Michael V. W., Masini, Emanuela, Sgambellone, Silvia, Unser, Andrea M., Ahmed, Feryan, Torrejon, Karen Y., Navratil, Tomas, Impagnatiello, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Physiology and Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960798/
https://www.ncbi.nlm.nih.gov/pubmed/33704360
http://dx.doi.org/10.1167/iovs.62.3.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960798/
https://www.ncbi.nlm.nih.gov/pubmed/33704360
http://dx.doi.org/10.1167/iovs.62.3.17

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