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The zinc-binding domain of mammalian prolyl-tRNA synthetase is indispensable for catalytic activity and organism viability
Aminoacyl-tRNA synthetases (AARS) participate in decoding the genome by catalyzing conjugation of amino acids to their cognate tRNAs. During evolution, biochemical and environmental conditions markedly influenced the sequence and structure of the 20 AARSs, revealing adaptations dictating canonical a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960942/ https://www.ncbi.nlm.nih.gov/pubmed/33748704 http://dx.doi.org/10.1016/j.isci.2021.102215 |