Umbilical cord-derived mesenchymal stromal cells immunomodulate and restore actin dynamics and phagocytosis of LPS-activated microglia via PI3K/Akt/Rho GTPase pathway

Microglia are the immune cells in the central nervous system surveying environment and reacting to various injuries. Activated microglia may cause impaired synaptic plasticity, therefore modulating and restoring them to neutral phenotype is crucial to counteract a pro-inflammatory, neurotoxic state....

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Detalles Bibliográficos
Autores principales: Mukai, Takeo, Di Martino, Elena, Tsuji, Shunichiro, Blomgren, Klas, Nagamura-Inoue, Tokiko, Ådén, Ulrika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961004/
https://www.ncbi.nlm.nih.gov/pubmed/33723246
http://dx.doi.org/10.1038/s41420-021-00436-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961004/
https://www.ncbi.nlm.nih.gov/pubmed/33723246
http://dx.doi.org/10.1038/s41420-021-00436-w

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