NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin

The exact mechanism of myocardial hypertrophy has not been completely elucidated. NOD-like receptor protein 3 (NLRP3) and the pyroptotic cascade play a critical role in cardiac hypertrophy and inflammation. The myokine irisin can inhibit NLRP3 activation, although its exact mechanism of action is un...

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Detalles Bibliográficos
Autores principales: Yue, Rongchuan, Zheng, Zaiyong, Luo, Yu, Wang, Xiaobo, Lv, Mingming, Qin, Dan, Tan, Qingqing, Zhang, Yulong, Wang, Tao, Hu, Houxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961005/
https://www.ncbi.nlm.nih.gov/pubmed/33723236
http://dx.doi.org/10.1038/s41420-021-00434-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961005/
https://www.ncbi.nlm.nih.gov/pubmed/33723236
http://dx.doi.org/10.1038/s41420-021-00434-y

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