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NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin

The exact mechanism of myocardial hypertrophy has not been completely elucidated. NOD-like receptor protein 3 (NLRP3) and the pyroptotic cascade play a critical role in cardiac hypertrophy and inflammation. The myokine irisin can inhibit NLRP3 activation, although its exact mechanism of action is un...

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Detalles Bibliográficos
Autores principales:	Yue, Rongchuan, Zheng, Zaiyong, Luo, Yu, Wang, Xiaobo, Lv, Mingming, Qin, Dan, Tan, Qingqing, Zhang, Yulong, Wang, Tao, Hu, Houxiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961005/ https://www.ncbi.nlm.nih.gov/pubmed/33723236 http://dx.doi.org/10.1038/s41420-021-00434-y

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