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Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms

The seven 14-3-3 isoforms are highly abundant human proteins encoded by similar yet distinct genes. 14-3-3 proteins recognize phosphorylated motifs within numerous human and viral proteins. Here, we analyze by X-ray crystallography, fluorescence polarization, mutagenesis and fusicoccin-mediated modu...

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Detalles Bibliográficos
Autores principales:	Gogl, Gergo, Tugaeva, Kristina V., Eberling, Pascal, Kostmann, Camille, Trave, Gilles, Sluchanko, Nikolai N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961048/ https://www.ncbi.nlm.nih.gov/pubmed/33723253 http://dx.doi.org/10.1038/s41467-021-21908-8

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