Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides

γ-Secretase is responsible for the proteolysis of amyloid precursor protein (APP) into amyloid-beta (Aβ) peptides, which are centrally implicated in the pathogenesis of Alzheimer’s disease (AD). The biochemical mechanism of how processing by γ-secretase is regulated, especially as regards the intera...

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Detalles Bibliográficos
Autores principales: Liu, Lei, Lauro, Bianca M., Wolfe, Michael S., Selkoe, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961089/
https://www.ncbi.nlm.nih.gov/pubmed/33571524
http://dx.doi.org/10.1016/j.jbc.2021.100393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961089/
https://www.ncbi.nlm.nih.gov/pubmed/33571524
http://dx.doi.org/10.1016/j.jbc.2021.100393

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