Selective coactivation of α7- and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid–induced synaptic dysfunction

Beta-amyloid (Aβ) has been recognized as an early trigger in the pathogenesis of Alzheimer's disease (AD) leading to synaptic and cognitive impairments. Aβ can alter neuronal signaling through interactions with nicotinic acetylcholine receptors (nAChRs), contributing to synaptic dysfunction in...

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Detalles Bibliográficos
Autores principales: Roberts, Jessica P., Stokoe, Sarah A., Sathler, Matheus F., Nichols, Robert A., Kim, Seonil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961090/
https://www.ncbi.nlm.nih.gov/pubmed/33571523
http://dx.doi.org/10.1016/j.jbc.2021.100402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961090/
https://www.ncbi.nlm.nih.gov/pubmed/33571523
http://dx.doi.org/10.1016/j.jbc.2021.100402

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