Cargando…

Mass spectrometry imaging of phosphatidylcholine metabolism in lungs administered with therapeutic surfactants and isotopic tracers

Mass spectrometry imaging (MSI) visualizes molecular distributions throughout tissues but is blind to dynamic metabolic processes. Here, MSI with high mass resolution together with multiple stable isotope labeling provided spatial analyses of phosphatidylcholine (PC) metabolism in mouse lungs. Dysre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ellis, Shane R., Hall, Emily, Panchal, Madhuriben, Flinders, Bryn, Madsen, Jens, Koster, Grielof, Heeren, Ron.M.A., Clark, Howard W., Postle, Anthony D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961103/ https://www.ncbi.nlm.nih.gov/pubmed/33453219 http://dx.doi.org/10.1016/j.jlr.2021.100023

Ejemplares similares

Rapid Phospholipid Turnover after Surfactant Nebulization in Severe COVID-19 Infection: A Randomized Clinical Trial
por: Postle, Anthony D., et al.
Publicado: (2021)

Metabolism of a synthetic compared with a natural therapeutic pulmonary surfactant in adult mice
por: Madsen, Jens, et al.
Publicado: (2018)

Increased Alveolar Heparan Sulphate and Reduced Pulmonary Surfactant Amount and Function in the Mucopolysaccharidosis IIIA Mouse
por: Paget, Tamara L., et al.
Publicado: (2021)

Postnatal adaptations of phosphatidylcholine metabolism in extremely preterm infants: implications for choline and PUFA metabolism
por: Goss, Kevin C W, et al.
Publicado: (2020)

Targeted Drug and Metabolite Imaging: Desorption Electrospray Ionization Combined with Triple Quadrupole Mass Spectrometry
por: Lamont, Lieke, et al.
Publicado: (2018)

MALDI-2 Mass Spectrometry for Synthetic Polymer Analysis
por: Molina-Millán, Lidia, et al.
Publicado: (2023)

Lipidomic profiling in Crohn's disease: Abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition
por: Sewell, Gavin W., et al.
Publicado: (2012)

Quantitative mass spectrometry imaging of drugs and metabolites: a multiplatform comparison
por: Lamont, Lieke, et al.
Publicado: (2021)

Isotopic Tracers
Publicado: (1955)

Surfactant disaturated-phosphatidylcholine kinetics in acute respiratory distress syndrome by stable isotopes and a two compartment model
por: Cogo, Paola E, et al.
Publicado: (2007)

Spatial Localization of Vitamin D Metabolites in Mouse Kidney by Mass Spectrometry Imaging
por: Smith, Karl W., et al.
Publicado: (2020)

On‐tissue chemical derivatization in mass spectrometry imaging
por: Harkin, Carla, et al.
Publicado: (2021)

Correlation of lung mechanics with saturated phosphatidylcholine ratios and surfactant protein A in bronchoalveolar lavage fluid from infants with RSV induced respiratory failure
por: Tibby, SM, et al.
Publicado: (1999)

Recruitment and Retention of Urban Pregnant Women to a Clinical Study Administering an Oral Isotope Dietary Tracer
por: Koenig, Mary Dawn, et al.
Publicado: (2022)

High‐resolution ion mobility spectrometry–mass spectrometry for isomeric separation of prostanoids after Girard's reagent T derivatization
por: Lamont, Lieke, et al.
Publicado: (2022)

Stable Isotopic Tracer Phospholipidomics Reveals Contributions of Key Phospholipid Biosynthetic Pathways to Low Hepatocyte Phosphatidylcholine to Phosphatidylethanolamine Ratio Induced by Free Fatty Acids
por: Peng, Kang-Yu, et al.
Publicado: (2021)

Application of Isotope Tracer in Cross-Well Nanometre Tracer Testing
por: Pang, Yang, et al.
Publicado: (2022)

Insight into erythrocyte phospholipid molecular flux in healthy humans and in patients with acute respiratory distress syndrome
por: Dushianthan, Ahilanandan, et al.
Publicado: (2019)

In Vivo Effect of Pneumonia on Surfactant Disaturated-Phosphatidylcholine Kinetics in Newborn Infants
por: Facco, Maddalena, et al.
Publicado: (2014)

Exhaled breath particles as a novel tool to study lipid composition of epithelial lining fluid from the distal lung
por: Larsson, Per, et al.
Publicado: (2023)

Retracted: Application of Isotope Tracer in Cross-Well Nanometre Tracer Testing
por: Chemistry, International Journal of Analytical
Publicado: (2023)

Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes
por: Arts, Martijn, et al.
Publicado: (2017)

Abnormal liver phosphatidylcholine synthesis revealed in patients with acute respiratory distress syndrome
por: Dushianthan, Ahilanandan, et al.
Publicado: (2018)

Isotopes as Tracers of the Hawaiian Coffee-Producing Regions
por: Rodrigues, Carla, et al.
Publicado: (2011)

AssayR: A Simple Mass Spectrometry Software Tool for Targeted Metabolic and Stable Isotope Tracer Analyses
por: Wills, Jimi, et al.
Publicado: (2017)

Nanoplasmonic Sensing and Capillary Electrophoresis for Fast Screening of Interactions between Phosphatidylcholine Biomembranes and Surfactants
por: Duša, Filip, et al.
Publicado: (2018)

A Multimodal SIMS/MALDI Mass Spectrometry Imaging Source with Secondary Electron Imaging Capabilities for Use with timsTOF Instruments
por: Krijnen, Kasper, et al.
Publicado: (2023)

Uranium isotopes as a tracer of groundwater transport studies
por: Grabowski, P., et al.
Publicado: (2011)

Decreased surfactant phosphatidylcholine synthesis in neonates with congenital diaphragmatic hernia during extracorporeal membrane oxygenation
por: Janssen, Daphne J., et al.
Publicado: (2009)

Disaturated-phosphatidylcholine and Surfactant protein-B turnover in human acute lung injury and in control patients
por: Simonato, Manuela, et al.
Publicado: (2011)

Isomer-Resolved Mass Spectrometry Imaging of Acidic Phospholipids
por: Claes, Britt S. R., et al.
Publicado: (2023)

Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging
por: Scott, Alison J., et al.
Publicado: (2019)

Translational imaging mass spectrometry: From CERN to the surgeon
por: Heeren, Ron
Publicado: (2018)

Does Whole-Body Hypothermia in Neonates with Hypoxic–Ischemic Encephalopathy Affect Surfactant Disaturated-Phosphatidylcholine Kinetics?
por: Nespeca, Matteo, et al.
Publicado: (2016)

THE METHOD OF ISOTOPIC TRACERS APPLIED TO THE STUDY OF ACTIVE ION TRANSPORT
Publicado: (1959)

Studies of Human Lead Metabolism by Use of Stable Isotope Tracers
por: Rabinowitz, M., et al.
Publicado: (1974)

Stable isotopes as tracers of trophic interactions in marine mutualistic symbioses
por: Ferrier‐Pagès, Christine, et al.
Publicado: (2018)

Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics
por: Williams, Holden C., et al.
Publicado: (2020)

Optimization of Sample Preparation and Instrumental Parameters for the Rapid Analysis of Drugs of Abuse in Hair samples by MALDI-MS/MS Imaging
por: Flinders, Bryn, et al.
Publicado: (2017)

Isotopes as Tracers in Marine Environmental Studies – A Forthcoming Collection of Papers in the Isotopes in the Environment Domain
por: Povinec, Pavel
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_misvclb04nlu8uofrgrobe6apm