Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model

PURPOSE: SARS-CoV-2 engages human ACE2 through its spike (S) protein receptor binding domain (RBD) to enter the host cell. Recent computational studies have reported that withanone and withaferin A, phytochemicals found in Withania somnifera, target viral main protease (M(Pro)) and host transmembran...

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Detalles Bibliográficos
Autores principales: Balkrishna, Acharya, Pokhrel, Subarna, Singh, Hoshiyar, Joshi, Monali, Mulay, Vallabh Prakash, Haldar, Swati, Varshney, Anurag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961299/
https://www.ncbi.nlm.nih.gov/pubmed/33737804
http://dx.doi.org/10.2147/DDDT.S292805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961299/
https://www.ncbi.nlm.nih.gov/pubmed/33737804
http://dx.doi.org/10.2147/DDDT.S292805

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