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Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model
PURPOSE: SARS-CoV-2 engages human ACE2 through its spike (S) protein receptor binding domain (RBD) to enter the host cell. Recent computational studies have reported that withanone and withaferin A, phytochemicals found in Withania somnifera, target viral main protease (M(Pro)) and host transmembran...
Autores principales: | Balkrishna, Acharya, Pokhrel, Subarna, Singh, Hoshiyar, Joshi, Monali, Mulay, Vallabh Prakash, Haldar, Swati, Varshney, Anurag |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961299/ https://www.ncbi.nlm.nih.gov/pubmed/33737804 http://dx.doi.org/10.2147/DDDT.S292805 |
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