Ca(2+) Signalling Induced by NGF Identifies a Subset of Capsaicin-Excitable Neurons Displaying Enhanced Chemo-Nociception in Dorsal Root Ganglion Explants from Adult pirt-GCaMP3 Mouse

Nociceptors sense hazards via plasmalemmal cation channels, including transient receptor potential vanilloid 1 (TRPV1). Nerve growth factor (NGF) sensitises TRPV1 to capsaicin (CAPS), modulates nociceptor excitability and induces thermal hyperalgesia, but cellular mechanisms remain unclear. Confocal...

Descripción completa

Detalles Bibliográficos
Autores principales: Lawrence, Gary W., Zurawski, Tomas H., Dolly, J. Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961361/
https://www.ncbi.nlm.nih.gov/pubmed/33806699
http://dx.doi.org/10.3390/ijms22052589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961361/
https://www.ncbi.nlm.nih.gov/pubmed/33806699
http://dx.doi.org/10.3390/ijms22052589

Ejemplares similares