AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis

The role of the PYHIN family member absent in melanoma 2 (AIM2), another important inflammasome sensor, in EAE remains unclear. In this study, we found that AIM2 negatively regulates the pathogenesis of EAE independent of inflammasome activation. AIM2 deficiency enhanced microglia activation and inf...

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Detalles Bibliográficos
Autores principales: Ma, Chunmei, Li, Sheng, Hu, Yingchao, Ma, Yan, Wu, Yuqing, Wu, Chunyan, Liu, Xue, Wang, Bingwei, Hu, Gang, Zhou, Jiawei, Yang, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961553/
https://www.ncbi.nlm.nih.gov/pubmed/33710283
http://dx.doi.org/10.1084/jem.20201796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961553/
https://www.ncbi.nlm.nih.gov/pubmed/33710283
http://dx.doi.org/10.1084/jem.20201796

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