Targeted Delivery of Soluble Guanylate Cyclase (sGC) Activator Cinaciguat to Renal Mesangial Cells via Virus-Mimetic Nanoparticles Potentiates Anti-Fibrotic Effects by cGMP-Mediated Suppression of the TGF-β Pathway

Diabetic nephropathy (DN) ranks among the most detrimental long-term effects of diabetes, affecting more than 30% of all patients. Within the diseased kidney, intraglomerular mesangial cells play a key role in facilitating the pro-fibrotic turnover of extracellular matrix components and a progredien...

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Detalles Bibliográficos
Autores principales: Fleischmann, Daniel, Harloff, Manuela, Maslanka Figueroa, Sara, Schlossmann, Jens, Goepferich, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961750/
https://www.ncbi.nlm.nih.gov/pubmed/33806499
http://dx.doi.org/10.3390/ijms22052557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961750/
https://www.ncbi.nlm.nih.gov/pubmed/33806499
http://dx.doi.org/10.3390/ijms22052557

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