β-Lactamase inhibition profile of new amidine-substituted diazabicyclooctanes

The diazabicyclooctane (DBO) scaffold is the backbone of non-β-lactam-based second generation β-lactamase inhibitors. As part of our efforts, we have synthesized a series of DBO derivatives A1–23 containing amidine substituents at the C2 position of the bicyclic ring. These compounds, alone and in c...

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Detalles Bibliográficos
Autores principales: Iqbal, Zafar, Zhai, Lijuan, Gao, Yuanyu, Tang, Dong, Ma, Xueqin, Ji, Jinbo, Sun, Jian, Ji, Jingwen, Liu, Yuanbai, Jiang, Rui, Mu, Yangxiu, He, Lili, Yang, Haikang, Yang, Zhixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961884/
https://www.ncbi.nlm.nih.gov/pubmed/33777246
http://dx.doi.org/10.3762/bjoc.17.60

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961884/
https://www.ncbi.nlm.nih.gov/pubmed/33777246
http://dx.doi.org/10.3762/bjoc.17.60

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