Cargando…

Dispirooxindoles Based on 2-Selenoxo-Imidazolidin-4-Ones: Synthesis, Cytotoxicity and ROS Generation Ability

A regio- and diastereoselective synthesis of two types of dispiro derivatives of 2-selenoxoimidazolidin-4-ones, differing in the position of the nitrogen atom in the central pyrrolidine ring of the spiro-fused system—namely, 2-selenoxodispiro[imidazolidine-4,3′-pyrrolidine-2′,3″-indoline]-2″,5-dione...

Descripción completa

Detalles Bibliográficos
Autores principales:	Novotortsev, Vladimir K., Kukushkin, Maxim E., Tafeenko, Viktor A., Skvortsov, Dmitry A., Kalinina, Marina A., Timoshenko, Roman V., Chmelyuk, Nelly S., Vasilyeva, Liliya A., Tarasevich, Boris N., Gorelkin, Petr V., Erofeev, Alexander S., Majouga, Alexander G., Zyk, Nikolai V., Beloglazkina, Elena K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961907/ https://www.ncbi.nlm.nih.gov/pubmed/33807662 http://dx.doi.org/10.3390/ijms22052613

Ejemplares similares

Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles
por: Kukushkin, Maksim, et al.
Publicado: (2021)

Dispirooxindole-β-Lactams: Synthesis via Staudinger Ketene-Imine Cycloaddition and Biological Evaluation
por: Filatov, Vadim E., et al.
Publicado: (2022)

Synthesis of 1,3-diaryl-spiro[azetidine-2,3′-indoline]-2′,4-diones via the Staudinger reaction: cis- or trans-diastereoselectivity with different addition modes
por: Filatov, Vadim, et al.
Publicado: (2020)

Aβ-Targeting Bifunctional Chelators (BFCs) for Potential Therapeutic and PET Imaging Applications
por: Krasnovskaya, Olga, et al.
Publicado: (2022)

Tacrine-Based Hybrids: Past, Present, and Future
por: Bubley, Anna, et al.
Publicado: (2023)

Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction
por: Beloglazkina, Anastasia, et al.
Publicado: (2020)

Copper Coordination Compounds as Biologically Active Agents
por: Krasnovskaya, Olga, et al.
Publicado: (2020)

Pt(IV) Prodrugs with NSAIDs as Axial Ligands
por: Spector, Daniil, et al.
Publicado: (2021)

[4+2]-Cycloaddition to 5-Methylidene-Hydantoins and 5-Methylidene-2-Thiohydantoins in the Synthesis of Spiro-2-Chalcogenimidazolones
por: Shybanov, Dmitry E., et al.
Publicado: (2023)

Metals in Imaging of Alzheimer’s Disease
por: Krasnovskaya, Olga, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity
por: Ivanenkov, Yan A., et al.
Publicado: (2023)

Synthesis and Preclinical Evaluation of Small-Molecule Prostate-Specific Membrane Antigen-Targeted Abiraterone Conjugate
por: Machulkin, Aleksei E., et al.
Publicado: (2022)

Copper coordination compounds with (5Z,5Z′)-2,2′-(alkane-α,ω-diyldiselenyl)-bis-5-(2-pyridylmethylene)-3,5-dihydro-4H-imidazol-4-ones. Comparison with sulfur analogue
por: Finko, Alexander V., et al.
Publicado: (2022)

[3+2]-Cycloaddition of azomethine ylides to 5-methylidene-3-aryl-2-сhalcogen-imidazolones: access to dispiro indolinone-pyrrolidine-imidazolones
por: Kukushkin, Maxim E., et al.
Publicado: (2022)

cis-Diastereoselective Synthesis of Spirooxindolo-β-Lactams by Staudinger Cycloaddition with TsCl as Activating Co-reagent
por: Filatov, Vadim E., et al.
Publicado: (2021)

Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates
por: Zyk, Nikolai Y., et al.
Publicado: (2023)

Recent Advances in Nanopore Technology for Copper Detection and Their Potential Applications
por: Vaneev, Alexander N., et al.
Publicado: (2023)

Recent Advances in (64)Cu/(67)Cu-Based Radiopharmaceuticals
por: Krasnovskaya, Olga O., et al.
Publicado: (2023)

Nano- and Microsensors for In Vivo Real-Time Electrochemical Analysis: Present and Future Perspectives
por: Vaneev, Alexander N., et al.
Publicado: (2022)

Novel Pumping Methods for Microfluidic Devices: A Comprehensive Review
por: Iakovlev, Aleksei P., et al.
Publicado: (2022)

Facile Access to 2-Selenoxo-1,2,3,4-tetrahydro-4-quinazolinone Scaffolds and Corresponding Diselenides via Cyclization between Methyl Anthranilate and Isoselenocyanates: Synthesis and Structural Features
por: Osmanov, Vladimir K., et al.
Publicado: (2022)

Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen
por: Petrov, Stanislav A., et al.
Publicado: (2020)

Novel method for rapid toxicity screening of magnetic nanoparticles
por: Erofeev, A., et al.
Publicado: (2018)

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity
por: Garanina, Anastasiia S., et al.
Publicado: (2021)

Analytical Models for Measuring the Mechanical Properties of Yeast
por: Savin, Nikita, et al.
Publicado: (2023)

Label-free sensitive detection of influenza virus using PZT discs with a synthetic sialylglycopolymer receptor layer
por: Erofeev, Alexander S., et al.
Publicado: (2019)

From Toxicity to Selectivity: Coculture of the Fluorescent Tumor and Non-Tumor Lung Cells and High-Throughput Screening of Anticancer Compounds
por: Skvortsov, D.A., et al.
Publicado: (2021)

Diastereoselective synthesis of dispirooxindoles via [3+2] cycloaddition of azomethine ylides to 3-phenacylideneoxindoles and evaluation of their cytotoxicity
por: Huang, Ying, et al.
Publicado: (2018)

Sensing Cells-Peptide Hydrogel Interaction In Situ via Scanning Ion Conductance Microscopy
por: Tikhonova, Tatiana N., et al.
Publicado: (2022)

Investigation of the Antifungal and Anticancer Effects of the Novel Synthesized Thiazolidinedione by Ion-Conductance Microscopy
por: Savin, Nikita, et al.
Publicado: (2023)

ROS Production by a Single Neutrophil Cell and Neutrophil Population upon Bacterial Stimulation
por: Pleskova, Svetlana N., et al.
Publicado: (2023)

Imidazolidine Hydride Donors in Palladium-Catalyzed Alkyne Hydroarylation
por: Tun, Soe L., et al.
Publicado: (2022)

An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions
por: Huang, Zhibin, et al.
Publicado: (2012)

A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction
por: He, Jun, et al.
Publicado: (2013)

Microbiological Evaluation of 4-substituted-imidazolidine Derivatives
por: Khan, M. S. Y., et al.
Publicado: (2012)

Superoxide Dismutase 1 Nanoparticles (Nano-SOD1) as a Potential Drug for the Treatment of Inflammatory Eye Diseases
por: Vaneev, Alexander N., et al.
Publicado: (2021)

Encapsulins: Structure, Properties, and Biotechnological Applications
por: Chmelyuk, Nelly S., et al.
Publicado: (2023)

Photodynamic therapy of melanoma by blue-light photoactivation of flavin mononucleotide
por: Akasov, R. A., et al.
Publicado: (2019)

Synthesis, (123)I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures
por: Hasnowo, Lutfi A., et al.
Publicado: (2023)

Scanning Ion-Conductance Microscopy for Studying Mechanical Properties of Neuronal Cells during Local Delivery of Glutamate
por: Kolmogorov, Vasilii, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ban521f48m3398cqauvufk68uv