Advanced Spectroscopy and APBS Modeling for Determination of the Role of His190 and Trp103 in Mouse Thymidylate Synthase Interaction with Selected dUMP Analogues

A homo-dimeric enzyme, thymidylate synthase (TS), has been a long-standing molecular target in chemotherapy. To further elucidate properties and interactions with ligands of wild-type mouse thymidylate synthase (mTS) and its two single mutants, H190A and W103G, spectroscopic and theoretical investig...

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Detalles Bibliográficos
Autores principales: Prokopowicz, Małgorzata, Jarmuła, Adam, Casamayou-Boucau, Yannick, Gordon, Fiona, Ryder, Alan, Sobich, Justyna, Maj, Piotr, Cieśla, Joanna, Zieliński, Zbigniew, Fita, Piotr, Rode, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962005/
https://www.ncbi.nlm.nih.gov/pubmed/33800923
http://dx.doi.org/10.3390/ijms22052661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962005/
https://www.ncbi.nlm.nih.gov/pubmed/33800923
http://dx.doi.org/10.3390/ijms22052661

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