Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex In Vitro

The nucleotide analog sofosbuvir, licensed for the treatment of hepatitis C, recently revealed activity against the Zika virus (ZIKV) in vitro and in animal models. However, the ZIKV genetic barrier to sofosbuvir has not yet been characterized. In this study, in vitro selection experiments were perf...

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Detalles Bibliográficos
Autores principales: Boccuto, Adele, Dragoni, Filippo, Picarazzi, Francesca, Lai, Alessia, Della Ventura, Carla, Veo, Carla, Giammarino, Federica, Saladini, Francesco, Zehender, Gianguglielmo, Zazzi, Maurizio, Mori, Mattia, Vicenti, Ilaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962015/
https://www.ncbi.nlm.nih.gov/pubmed/33800884
http://dx.doi.org/10.3390/ijms22052670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962015/
https://www.ncbi.nlm.nih.gov/pubmed/33800884
http://dx.doi.org/10.3390/ijms22052670

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