Cargando…

ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization

ATP13A2, a late endo-/lysosomal polyamine transporter, is implicated in a variety of neurodegenerative diseases, including Parkinson’s disease and Kufor–Rakeb syndrome, an early-onset atypical form of parkinsonism. Loss-of-function mutations in ATP13A2 result in lysosomal deficiency as a consequence...

Descripción completa

Detalles Bibliográficos
Autores principales:	Si, Jianmin, Van den Haute, Chris, Lobbestael, Evy, Martin, Shaun, van Veen, Sarah, Vangheluwe, Peter, Baekelandt, Veerle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962109/ https://www.ncbi.nlm.nih.gov/pubmed/33799982 http://dx.doi.org/10.3390/ijms22052689

Ejemplares similares

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2
por: Martin, Shaun, et al.
Publicado: (2016)

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity
por: Lobbestael, Evy, et al.
Publicado: (2020)

ATP13A4 Upregulation Drives the Elevated Polyamine Transport System in the Breast Cancer Cell Line MCF7
por: van Veen, Sarah, et al.
Publicado: (2023)

ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress
por: Vrijsen, Stephanie, et al.
Publicado: (2020)

ATP13A3 is a major component of the enigmatic mammalian polyamine transport system
por: Hamouda, Norin Nabil, et al.
Publicado: (2020)

Immunohistochemical detection of transgene expression in the brain using small epitope tags
por: Lobbestael, Evy, et al.
Publicado: (2010)

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration
por: Van Rompuy, Anne-Sophie, et al.
Publicado: (2015)

Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation
por: Cabezudo, Diego, et al.
Publicado: (2020)

Novel Green Fluorescent Polyamines to Analyze ATP13A2 and ATP13A3 Activity in the Mammalian Polyamine Transport System
por: Houdou, Marine, et al.
Publicado: (2023)

Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson’s disease
por: Torre-Muruzabal, Teresa, et al.
Publicado: (2019)

Mutated ATP10B increases Parkinson’s disease risk by compromising lysosomal glucosylceramide export
por: Martin, Shaun, et al.
Publicado: (2020)

Editorial: The Role of Lipids in the Pathogenesis of Parkinson's Disease
por: Baekelandt, Veerle, et al.
Publicado: (2020)

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2
por: Vancraenenbroeck, Renée, et al.
Publicado: (2014)

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
por: Oliveras-Salvá, Marusela, et al.
Publicado: (2013)

Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders
por: van Veen, Sarah, et al.
Publicado: (2014)

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies
por: Van der Perren, Anke, et al.
Publicado: (2020)

Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis
por: Cabezudo, Diego, et al.
Publicado: (2023)

Increased Levels of the Parkinson’s Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status
por: Di Leva, Francesca, et al.
Publicado: (2023)

The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology
por: Obergasteiger, Julia, et al.
Publicado: (2023)

Parkinson disease related ATP13A2 evolved early in animal evolution
por: Sørensen, Danny Mollerup, et al.
Publicado: (2018)

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions
por: Obergasteiger, Julia, et al.
Publicado: (2020)

Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks
por: Pulizzi, Rocco, et al.
Publicado: (2016)

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A
por: Madero-Pérez, Jesús, et al.
Publicado: (2018)

Long-Term Fate Mapping Using Conditional Lentiviral Vectors Reveals a Continuous Contribution of Radial Glia-Like Cells to Adult Hippocampal Neurogenesis in Mice
por: Aelvoet, Sarah-Ann, et al.
Publicado: (2015)

IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity
por: Pereira, Leticia, et al.
Publicado: (2015)

Transient and localized optogenetic activation of somatostatin-interneurons in mouse visual cortex abolishes long-term cortical plasticity due to vision loss
por: Scheyltjens, Isabelle, et al.
Publicado: (2018)

Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine
por: Li, Zhiling, et al.
Publicado: (2019)

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
por: Taymans, Jean-Marc, et al.
Publicado: (2011)

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism
por: Taymans, Jean-Marc, et al.
Publicado: (2014)

Leucine‐rich repeat kinase 2 interacts with p21‐activated kinase 6 to control neurite complexity in mammalian brain
por: Civiero, Laura, et al.
Publicado: (2015)

Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking
por: Waschbüsch, Dieter, et al.
Publicado: (2019)

Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB
por: Dekeyster, Eline, et al.
Publicado: (2015)

ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy
por: Lopes da Fonseca, Tomás, et al.
Publicado: (2014)

An integrated multi-electrode-optrode array for in vitro optogenetics
por: Welkenhuysen, Marleen, et al.
Publicado: (2016)

Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structures
por: Xu, Ya-Nan, et al.
Publicado: (2012)

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson’s disease
por: Büttner, Sabrina, et al.
Publicado: (2013)

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration
por: Peralta Ramos, Javier María, et al.
Publicado: (2019)

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
por: Iannotta, Lucia, et al.
Publicado: (2020)

Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization
por: De Wit, T., et al.
Publicado: (2018)

A Feasibility Study to Investigate Chemogenetic Modulation of the Locus Coeruleus by Means of Single Unit Activity
por: Stevens, Latoya, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3o2if4ib10j8jialg8htbb7rib