Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P

Mitochondrial diseases linked to mutations in mitochondrial (mt) tRNA sequences are common. However, the contributions of these tRNA mutations to the development of diseases is mostly unknown. Mutations may affect interactions with (mt)tRNA maturation enzymes or protein synthesis machinery leading t...

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Detalles Bibliográficos
Autores principales: Karasik, Agnes, Wilhelm, Catherine A., Fierke, Carol A., Koutmos, Markos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962481/
https://www.ncbi.nlm.nih.gov/pubmed/33380464
http://dx.doi.org/10.1261/rna.077198.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962481/
https://www.ncbi.nlm.nih.gov/pubmed/33380464
http://dx.doi.org/10.1261/rna.077198.120

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