Cargando…

Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer

Caspase 8 is a protein involved in the process of cell apoptosis, which may affect the efficacy of anti-cancer treatment. The aim of our study was to determine the impact of polymorphisms in the CASP-8 gene encoding caspase 8 on the prognosis in non-small-cell lung cancer (NSCLC). The study involved...

Descripción completa

Detalles Bibliográficos
Autores principales: Szczyrek, Michał, Mlak, Radosław, Szudy-Szczyrek, Aneta, Kędziora, Karolina, Małecka-Massalska, Teresa, Krawczyk, Paweł, Milanowski, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962636/
https://www.ncbi.nlm.nih.gov/pubmed/33800294
http://dx.doi.org/10.3390/jcm10051126
_version_ 1783665500974219264
author Szczyrek, Michał
Mlak, Radosław
Szudy-Szczyrek, Aneta
Kędziora, Karolina
Małecka-Massalska, Teresa
Krawczyk, Paweł
Milanowski, Janusz
author_facet Szczyrek, Michał
Mlak, Radosław
Szudy-Szczyrek, Aneta
Kędziora, Karolina
Małecka-Massalska, Teresa
Krawczyk, Paweł
Milanowski, Janusz
author_sort Szczyrek, Michał
collection PubMed
description Caspase 8 is a protein involved in the process of cell apoptosis, which may affect the efficacy of anti-cancer treatment. The aim of our study was to determine the impact of polymorphisms in the CASP-8 gene encoding caspase 8 on the prognosis in non-small-cell lung cancer (NSCLC). The study involved 99 patients with newly diagnosed locally advanced or metastatic NSCLC treated with platinum-based chemotherapy. The presence of the GG genotype was associated with distant metastases, smoking, and a family history of cancer. The higher risk of early progression was associated with weight loss and the CASP-8 genotype (GG vs. AG or AA: 20.51% vs. 2.86%). The higher risk of progression-free survival (PFS) shortening was associated with a higher stage of disease (hazard ratio (HR) = 2.50, 95% CI: 1.61–3.89, p < 0.0001), distant metastases (HR = 2.30, 95% CI: 1.42–3.72, p = 0.0016), and the GG genotype (HR = 1.68, 95% CI: 1.10–2.57, p = 0.0152). The influence of the GG genotype on the PFS was confirmed in a multivariate analysis (HR = 1.80, 95% CI: 1.06–3.05, p = 0.0317). We did not confirm the influence of CASP-8 genotypes on the overall survival (OS).
format Online
Article
Text
id pubmed-7962636
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79626362021-03-17 Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer Szczyrek, Michał Mlak, Radosław Szudy-Szczyrek, Aneta Kędziora, Karolina Małecka-Massalska, Teresa Krawczyk, Paweł Milanowski, Janusz J Clin Med Article Caspase 8 is a protein involved in the process of cell apoptosis, which may affect the efficacy of anti-cancer treatment. The aim of our study was to determine the impact of polymorphisms in the CASP-8 gene encoding caspase 8 on the prognosis in non-small-cell lung cancer (NSCLC). The study involved 99 patients with newly diagnosed locally advanced or metastatic NSCLC treated with platinum-based chemotherapy. The presence of the GG genotype was associated with distant metastases, smoking, and a family history of cancer. The higher risk of early progression was associated with weight loss and the CASP-8 genotype (GG vs. AG or AA: 20.51% vs. 2.86%). The higher risk of progression-free survival (PFS) shortening was associated with a higher stage of disease (hazard ratio (HR) = 2.50, 95% CI: 1.61–3.89, p < 0.0001), distant metastases (HR = 2.30, 95% CI: 1.42–3.72, p = 0.0016), and the GG genotype (HR = 1.68, 95% CI: 1.10–2.57, p = 0.0152). The influence of the GG genotype on the PFS was confirmed in a multivariate analysis (HR = 1.80, 95% CI: 1.06–3.05, p = 0.0317). We did not confirm the influence of CASP-8 genotypes on the overall survival (OS). MDPI 2021-03-08 /pmc/articles/PMC7962636/ /pubmed/33800294 http://dx.doi.org/10.3390/jcm10051126 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szczyrek, Michał
Mlak, Radosław
Szudy-Szczyrek, Aneta
Kędziora, Karolina
Małecka-Massalska, Teresa
Krawczyk, Paweł
Milanowski, Janusz
Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer
title Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer
title_full Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer
title_fullStr Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer
title_full_unstemmed Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer
title_short Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer
title_sort polymorphisms in the gene encoding caspase 8 may predict the response to first-line platinum-based chemotherapy in locally advanced or advanced non-small-cell lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962636/
https://www.ncbi.nlm.nih.gov/pubmed/33800294
http://dx.doi.org/10.3390/jcm10051126
work_keys_str_mv AT szczyrekmichał polymorphismsinthegeneencodingcaspase8maypredicttheresponsetofirstlineplatinumbasedchemotherapyinlocallyadvancedoradvancednonsmallcelllungcancer
AT mlakradosław polymorphismsinthegeneencodingcaspase8maypredicttheresponsetofirstlineplatinumbasedchemotherapyinlocallyadvancedoradvancednonsmallcelllungcancer
AT szudyszczyrekaneta polymorphismsinthegeneencodingcaspase8maypredicttheresponsetofirstlineplatinumbasedchemotherapyinlocallyadvancedoradvancednonsmallcelllungcancer
AT kedziorakarolina polymorphismsinthegeneencodingcaspase8maypredicttheresponsetofirstlineplatinumbasedchemotherapyinlocallyadvancedoradvancednonsmallcelllungcancer
AT małeckamassalskateresa polymorphismsinthegeneencodingcaspase8maypredicttheresponsetofirstlineplatinumbasedchemotherapyinlocallyadvancedoradvancednonsmallcelllungcancer
AT krawczykpaweł polymorphismsinthegeneencodingcaspase8maypredicttheresponsetofirstlineplatinumbasedchemotherapyinlocallyadvancedoradvancednonsmallcelllungcancer
AT milanowskijanusz polymorphismsinthegeneencodingcaspase8maypredicttheresponsetofirstlineplatinumbasedchemotherapyinlocallyadvancedoradvancednonsmallcelllungcancer