PSMA-D4 Radioligand for Targeted Therapy of Prostate Cancer: Synthesis, Characteristics and Preliminary Assessment of Biological Properties

A new PSMA ligand (PSMA-D4) containing the Glu-CO-Lys pharmacophore connected with a new linker system (L-Trp-4-Amc) and chelator DOTA was developed for radiolabeling with therapeutic radionuclides. Herein we describe the synthesis, radiolabeling, and preliminary biological evaluation of the novel P...

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Detalles Bibliográficos
Autores principales: Garnuszek, Piotr, Karczmarczyk, Urszula, Maurin, Michał, Sikora, Arkadiusz, Zaborniak, Jolanta, Pijarowska-Kruszyna, Justyna, Jaroń, Antoni, Wyczółkowska, Monika, Wojdowska, Wioletta, Pawlak, Dariusz, Lipiński, Piotr F. J., Mikołajczak, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962978/
https://www.ncbi.nlm.nih.gov/pubmed/33800517
http://dx.doi.org/10.3390/ijms22052731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962978/
https://www.ncbi.nlm.nih.gov/pubmed/33800517
http://dx.doi.org/10.3390/ijms22052731

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